The King lab develops and applies precision measurement and analysis capabilities at the intersection of physics, molecular biology, and nanotechnology.
Membrane proteins are difficult to characterize via traditional techniques, yet they constitute ~30% of proteins expressed in cells and perform critical functions. A primary goal of our research is to study individual membrane proteins with precision approaches, illuminating key physical attributes.
To accomplish this, we apply atomic force microscopy (AFM) and other techniques. AFM can reveal conformations, conformational dynamics, and structural energetics of membrane proteins in near-native conditions.